René Schlesier

Areas of research

 

• Expertise in heterologous expression and analytical characterization of proteins/active ingredients
• Research and development of complex oral multispecies biofilm models for the evaluation of oral and dental care products
• Development and characterization of oral and dental-specific active ingredients 

 

Career

 

Acedemic Career 

 

Since 10/2025

Research associate in the »Characterization of Medical and Cosmetic Care Products« group in the »Biological and Macromolecular Materials« business unit, Fraunhofer IMWS

02/2015 – 09/2025

Research associate and project manager for biological safety at NOMAD Bioscience GmbH in Halle (Saale), focusing on transient transformation of crops, development of viral vectors, optimization of transient expression of heterologous proteins in plants, project coordination, and project acquisition

03/2015

Doctorate at the Institute of Biology, Faculty of Natural Sciences I at Martin Luther University Halle-Wittenberg with the cumulative dissertation »On action-dependent protein transport at the thylakoid membrane: membrane interaction, receptor binding, and translocation of the chimeric 16/23 protein«

10/2008 – 02/2014

Research assistant at the Faculty of Natural Sciences I at Martin Luther University Halle-Wittenberg, Institute of Biology, Department of General Botany (Prof. Ralf-Bernd Klösgen) with a focus on »Transport of folded proteins at the thylakoid membrane of higher plants, investigation of the membrane interaction behavior of proteins at native and artificial biomembranes.«

11/2005 – 04/2006

Research assistant at the Faculty of Natural Sciences I of Martin Luther University Halle-Wittenberg, Institute of Biochemistry/Biotechnology, Department of Technical Biochemistry (Prof. Reiner Rudolph) with a focus on »Refolding efficiency of recombinantly produced proteins«

10/2003 – 09/2008

Studied biochemistry/biotechnology (Dipl. Biochem.) at the Faculty of Natural Sciences I at Martin Luther University Halle-Wittenberg, Institute of Biochemistry/Biotechnology; thesis topic:  »Characterization of an early translocation intermediate during DpH/Tat-dependent protein transport across the thylakoid membrane,« diploma 2008

 

Awards

04/2011 – 03/2013

Stipendium der Graduiertenförderung des Landes Sachsen-Anhalt

 

Publications

 

Torti, S.*, Schlesier, R.*, Thümmler, A., Bartels, D., Römer, P., Koch, B., Werner, S., Panwar, V., Kanyuka, K., Wirén, N.V., Jones, J.D.G., Hause, G., Giritch, A., Gleba, Y. (2021) Nat. Plants. Feb;7(2),159-171. (*)

Both authors contributed equally to this work.

 

Torti, S., Schlesier, R., Giritch, A., Gleba, Y. (2020) Method of improving potexviral vector stability. Patent publication number: 20200255847.

 

Schlesier, R. and Klösgen, R. B. (2015) C-terminal truncation of a Tat passenger protein affects its membrane translocation by interfering with receptor binding. Biol. Chem., 96, 349-57.

 

Dittmar, J., Schlesier, R., and Klösgen, R.B. (2013) Tat transport of a Sec passenger leads to both completely translocated as well as membrane-arrested passenger proteins. Biochim. Biophys. Acta, 1843, 446-453.

 

Hauer, R.S.*, Schlesier, R.*, Heilmann, K., Dittmar, J., Jakob, M., and Klösgen, R.B. (2013) Enough is enough: TatA demand during Tat-dependent protein transport. Biochim. Biophys. Acta, 1833, 957-965. (*) Both authors contributed equally to this work.

 

Schlesier, R. and Klösgen, R.B. (2010) Twin arginine translocation (Tat)-dependent protein transport: the passenger protein participates in the initial membrane binding step. Biol. Chem., 391,1411-1417.